Nummer 1-hits in de Billboard Hot 100 in 1981
Deze hits stonden in 1981 op nummer 1 in de Billboard Hot 100
| Datum | Artiest | Titel |
| 3 januari | John Lennon | (Just like) Starting over |
| 10 januari | John Lennon | (Just like) Starting over |
| 17 januari | John Lennon | (Just like) Starting over |
| 24 januari | John Lennon | (Just like) Starting over |
| 31 januari | Blondie | The tide is high |
| 7 februari | Kool & The Gang | Celebration |
| 14 februari | Kool & The Gang | Celebration |
| 21 februari | Dolly Parton | 9 to 5 |
| 28 februari | Eddie Rabbitt | I love a rainy night |
| 7 maart | Eddie Rabbitt | I love a rainy night |
| 14 maart | Dolly Parton | 9 to 5 |
| 21 maart | REO Speedwagon | Keep on loving you |
| 28 maart | Blondie | Rapture |
| 4 april | Blondie | Rapture |
| 11 april | Daryl Hall & John Oates | Kiss on my list |
| 18 april | Daryl Hall & John Oates | Kiss on my list |
| 25 april | Daryl Hall & John Oates | Kiss on my list |
| 2 mei | Sheena Easton | Morning train (Nine to five) |
| 9 mei | Sheena Easton | Morning train (Nine to five) |
| 16 mei | Kim Carnes | Bette Davis eyes |
| 23 mei | Kim Carnes | Bette Davis eyes |
| 30 mei | Kim Carnes | Bette Davis eyes |
| 6 juni | Kim Carnes | Bette Davis eyes |
| 13 juni | Kim Carnes | Bette Davis eyes |
| 20 juni | Stars On 45 | Medley: Intro Venus / Sugar sugar / No reply / I’ll be back / Drive my car / Do you want to know a secret / We can work it out / I should have known better / Nowhere man / You’re going to lose that girl / Stars on 45 |
| 27 juni | Kim Carnes | Bette Davis eyes |
| 4 juli | Kim Carnes | Bette Davis eyes |
| 11 juli | Kim Carnes | Bette Davis eyes |
| 18 juli | Kim Carnes | Bette Davis eyes |
| 25 juli | Air Supply | The one that you love |
| 1 augustus | Rick Springfield | Jessie's girl |
| 8 augustus | Rick Springfield | Jessie's girl |
| 15 augustus | Diana Ross & Lionel Richie | Endless love |
| 22 augustus | Diana Ross & Lionel Richie | Endless love |
| 29 augustus | Diana Ross & Lionel Richie | Endless love |
| 5 september | Diana Ross & Lionel Richie | Endless love |
| 12 september | Diana Ross & Lionel Richie | Endless love |
| 19 september | Diana Ross & Lionel Richie | Endless love |
| 26 september | Diana Ross & Lionel Richie | Endless love |
| 3 oktober | Diana Ross & Lionel Richie | Endless love |
| 10 oktober | Diana Ross & Lionel Richie | Endless love |
| 17 oktober | Christopher Cross | Arthur's theme (Best that you can do) |
| 24 oktober | Christopher Cross | Arthur's theme (Best that you can do) |
| 31 oktober | Christopher Cross | Arthur's theme (Best that you can do) |
| 7 november | Daryl Hall & John Oates | Private eyes |
| 14 november | Daryl Hall & John Oates | Private eyes |
| 21 november | Olivia Newton-John | Physical |
| 28 november | Olivia Newton-John | Physical |
| 5 december | Olivia Newton-John | Physical |
| 12 december | Olivia Newton-John | Physical |
| 19 december | Olivia Newton-John | Physical |
| 26 december | Olivia Newton-John | Physical |
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