Nummer 1-hits in de Billboard Hot 100 in 1980
Deze hits stonden in 1980 op nummer 1 in de Billboard Hot 100
| Datum | Artiest | Titel |
| 5 januari | KC & the Sunshine Band | Please don't go |
| 12 januari | Rupert Holmes | Escape (Piña colada song) |
| 19 januari | Michael Jackson | Rock with you |
| 26 januari | Michael Jackson | Rock with you |
| 2 februari | Michael Jackson | Rock with you |
| 9 februari | Michael Jackson | Rock with you |
| 16 februari | The Captain & Tenille | Do that to me one more time |
| 23 februari | Queen | Crazy little thing called love |
| 1 maart | Queen | Crazy little thing called love |
| 8 maart | Queen | Crazy little thing called love |
| 15 maart | Queen | Crazy little thing called love |
| 22 maart | Pink Floyd | Another brick in the wall |
| 29 maart | Pink Floyd | Another brick in the wall |
| 5 april | Pink Floyd | Another brick in the wall |
| 12 april | Pink Floyd | Another brick in the wall |
| 19 april | Blondie | Call me |
| 26 april | Blondie | Call me |
| 3 mei | Blondie | Call me |
| 10 mei | Blondie | Call me |
| 17 mei | Blondie | Call me |
| 24 mei | Blondie | Call me |
| 31 mei | Lipps Inc | Funkytown |
| 7 juni | Lipps Inc | Funkytown |
| 14 juni | Lipps Inc | Funkytown |
| 21 juni | Lipps Inc | Funkytown |
| 28 juni | Paul McCartney | Coming up (Live at Glasgow) |
| 5 juli | Paul McCartney | Coming up (Live at Glasgow) |
| 12 juli | Paul McCartney | Coming up (Live at Glasgow) |
| 19 juli | Billy Joel | It's still rock and roll to me |
| 26 juli | Billy Joel | It's still rock and roll to me |
| 2 augustus | Olivia Newton-John | Magic |
| 9 augustus | Olivia Newton-John | Magic |
| 16 augustus | Olivia Newton-John | Magic |
| 23 augustus | Olivia Newton-John | Magic |
| 30 augustus | Christopher Cross | Sailing |
| 6 september | Diana Ross | Upside down |
| 13 september | Diana Ross | Upside down |
| 20 september | Diana Ross | Upside down |
| 27 september | Diana Ross | Upside down |
| 4 oktober | Queen | Another one bites the dust |
| 11 oktober | Queen | Another one bites the dust |
| 18 oktober | Queen | Another one bites the dust |
| 25 oktober | Barbra Streisand | Woman in love |
| 1 november | Barbra Streisand | Woman in love |
| 8 november | Barbra Streisand | Woman in love |
| 15 november | Kenny Rogers | Lady |
| 22 november | Kenny Rogers | Lady |
| 29 november | Kenny Rogers | Lady |
| 6 december | Kenny Rogers | Lady |
| 13 december | Kenny Rogers | Lady |
| 20 december | Kenny Rogers | Lady |
| 27 december | John Lennon | (Just like) Starting over |
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