Treaty of Madrid (1750)
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The Treaty of Madrid was a document signed by Spain and Portugal concerning their empires and status of their slave plantations in what is now Brazil. Earlier treaties authored by both countries, and as mediated by the Catholic Church of Rome, stipulated that the Portuguese empire in South America could extend no further west than the 46th meridian. The Treaty of Madrid allowed further expansion of the slave holding Portuguese Empire at the expense the Empire of Spain. This expansion eventually led to the formation of the Empire of Brazil, which did not ban slavery until 1888. In their attempt to mark the new frontier, Spanish and Portuguese combined armies met the resistance of the seven (Jesuit) missions of the upper Uruguay, in what is known as The Guarani War (Guerra Guaranítica). The movie "The Mission" is based on these events.
The Guarani War occurred in 1756.