Terbutaline
From Wikipedia, the free encyclopedia
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Terbutaline
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| Systematic (IUPAC) name | |
| 5-(1-hydroxy-2-tert-butylamino-ethyl)benzene-1,3-diol | |
| Identifiers | |
| CAS number | 23031-25-6 |
| ATC code | R03AC03 R03CC03 |
| PubChem | 5403 |
| DrugBank | APRD00589 |
| Chemical data | |
| Formula | C12H19NO3 |
| Mol. weight | 225.284 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | gut wall, liver |
| Half life | 5.5-5.9 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
B |
| Legal status |
POM(UK) |
| Routes | oral, inhaled |
The drug Terbutaline (trade names Brethine, Bricanyl, or Brethaire) is a β2-adrenergic receptor agonist, used as a fast-acting bronchodilator (often used as a short-term asthma treatment) and as a tocolytic to delay premature labour. The inhaled form of terbutaline starts working within 15 minutes and can last up to 6 hours.
Terbutaline as a treatment for premature labour is an off-label use not approved by the FDA. Studies have suggested that terbutaline is a developmental neurotoxicant and may cause brain damage to the infant. (J Pharmacol Exp Ther. 2004 Feb;308(2):529-37. Epub 2003 Nov 10.)
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| Medications commonly used in asthma and COPD (primarily R03) edit | ||
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| Anticholinergics: | ||
| Short acting β2-agonists: |
Salbutamol, Terbutaline |
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| Long acting β2-agonists (LABA): | Clenbuterol, Formoterol, Salmeterol | |
| Corticosteroids: | ||
| Leukotriene antagonists: | ||
| Xanthines: | ||
| Mast cell stabilizers: | ||
| Combination products: |
Budesonide/formoterol, Fluticasone/salmeterol, Ipratropium/salbutamol |
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