Aminophylline
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Aminophylline
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Systematic (IUPAC) name | |
1,3-dimethyl-7H-purine-2,6-dione; ethane-1,2-diamine | |
Identifiers | |
CAS number | 317-34-0 |
ATC code | R03DA05 |
PubChem | 9433 |
DrugBank | APRD00329 |
Chemical data | |
Formula | C16H24N10O4 |
Mol. weight | 420.427 g/mol |
Pharmacokinetic data | |
Bioavailability | ? |
Protein binding | 60% |
Metabolism | ? |
Half life | 7-9 hours |
Excretion | ? |
Therapeutic considerations | |
Pregnancy cat. |
? |
Legal status |
P(UK) |
Routes | oral, i.v. |
Aminophylline is a drug combination that contains theophylline and ethylenediamine in 2:1 ratio.
Contents |
[edit] Properties
It is more soluble in water than theophylline. White or slightly yellowish granules or powder, having a slight ammoniacal odor and a bitter taste. Upon exposure to air, it gradually loses ethylenediamine and absorbs carbon dioxide with the liberation of free theophylline. Its solutions are alkaline to litmus. One g dissolves in 25 mL of water to give a clear solution; 1 g dissolved in 5 mL of water crystallizes upon standing, but redissolves when a small amount of ethylenediamine is added. Insoluble in alcohol and in ether.
[edit] Mechanism of action
Aminophylline is less potent and shorter-acting than theophylline. Its most common use is in the treatment of bronchial asthma.
[edit] Brand names
- Phyllocontin
- Truphylline
[edit] External links
Medications commonly used in asthma and COPD (primarily R03) edit | ||
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Anticholinergics: | ||
Short acting β2-agonists: | ||
Long acting β2-agonists (LABA): | Clenbuterol, Formoterol, Salmeterol | |
Corticosteroids: | ||
Leukotriene antagonists: | ||
Xanthines: |
Aminophylline, Theobromine, Theophylline |
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Mast cell stabilizers: | ||
Combination products: |
Budesonide/formoterol, Fluticasone/salmeterol, Ipratropium/salbutamol |