Tissue factor pathway inhibitor
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tissue factor pathway inhibitor
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| Identifiers | |
| Symbol(s) | TFPI LACI |
| Entrez | 7035 |
| OMIM | 152310 |
| RefSeq | NM_001032281 |
| UniProt | P10646 |
| Other data | |
| Locus | Chr. 2 q31-q32.1 |
Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-TF complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5nM.
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[edit] Genetics
The gene for TFPI is located on chromosome 2q31-q32.1, and has nine exons which span 70kb. The gene has not been completely sequenced yet. A similar gene, termed TFPI2, has been identified on chromosome 7q22; in addition to TFPI activity, its product also has retinal pigment epithelial cell growth-promoting properties.
[edit] Protein structure
TFPI has a relative molecular mass of 34000 to 40000 depending on the degree of proteolysis of the C-terminal region.
[edit] See also
[edit] External link
- Mendelian Inheritance in Man (OMIM) 152310 (TFPI1), Mendelian Inheritance in Man (OMIM) 600033 (TFPI2)
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| Coagulation factors: - Fibrin (I) - (Pro)thrombin (II) - FV - FVII - FVIII - FIX - FX - FXI - FXII - FXIII - HMWK - vWF - Tissue factor |
| Inhibitors: Antithrombin - Protein C - Protein S - Protein Z - ZPI - TFPI |
| Fibrinolysis: Plasmin - tPA/urokinase - PAI-1/2 - α2-AP - TAFI |
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