Proteus mirabilis
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| iProteus mirabilis | ||||||||||||||
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 P. mirabilis on an XLD agar plate.
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| Proteus mirabilis Hauser 1885 |
Proteus mirabilis is a Gram-negative, facultatively anaerobic bacterium. It shows swarming, motility, and urease activity. P. mirabilis causes 90% of all 'Proteus' infections. It belongs to the Tribe Proteae.
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[edit] Diagnosis
An alkaline urine sample is a possible sign of P. mirabilis.
P. mirabilis can be diagnosed in the lab due to characteristic swarming motility, and inability to metabolize lactose (on a MacConkey agar plate, for example.)
[edit] Disease
This bacterium has the ability to produce high levels of urease. Urease hydrolyzes urea to ammonia and thus makes the urine more alkaline. If left untreated, the increased alkalinity can lead to the formation of crystals of struvite, calcium carbonate, and/or apatite. The bacteria can be found throughout the stones, and these bacteria lurking in the stones can reinitiate infection after antibiotic treatment. Once the stones develop, over time they may grow large enough to cause obstruction and renal failure. Proteus can also cause wound infections, septicemia and pneumonias, mostly in hospitalized patients.
[edit] Treatment
P. mirabilis is generally susceptible to most antibiotics apart from tetracycline, however 10%–20% of P. mirabilis strains are also resistant to first generation cephalosporins and ampicillins.
[edit] Characteristics
P. mirabilis can utilize Urea and Citrate. It can produce Hydrogen Sulfide gas, and forms clear films on growth media. It is motile, possessing peritrichous flagella, and is known for its swarming ability. It is commonly found in the intestinal tract of humans. P. mirabilis is not pathogenic in Guinea Pigs or Chickens. It has the distinction of being the only pathogenic organism with a virulence factor named for late rock musician Frank Zappa.
The microorganism tests:
- Indole Negative and Nitrogen Reductase Positive
- Methyl Red Positive and Vogues-Proskauer Negative
- Catalase Positive and Cytochrome Oxidase Negative
- Phenylalanine Deaminase positive
[edit] External links
- "Proteus mirabilis and Urinary Tract Infection" [1].
