Proteinase 3
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proteinase 3
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Identifiers | |
Symbol(s) | PRTN3 |
Entrez | 5657 |
OMIM | 177020 |
RefSeq | NM_002777 |
UniProt | P24158 |
Other data | |
Locus | Chr. 19 p13.3 |
Proteinase 3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.