Glucuronosyltransferase
From Wikipedia, the free encyclopedia
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Glucuronosyltransferase
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| Identifiers | |
| Symbol(s) | UGT1A1 |
| Entrez | 54658 |
| OMIM | 191740 |
| RefSeq | NM_000463 |
| UniProt | P22309 |
| Other data | |
| EC number | 2.4.1.17 |
| Locus | Chr. 2 q37 |
Uridine 5'-diphospho-glucuronosyltransferase (UDP-glucuronosyltransferase, UGT) is a glycosyltransferase (EC 2.4.1.17) that catalyzes the glucuronidation reaction. This reaction involves the addition of sugars to lipids and other apolar xenobiotics and is an important step in the body's elimination of foreign substances (such as drugs) as well as endogenous substances (including toxins). UGP is present in humans, other animals, plants, and bacteria.
The glucuronidation reaction consists of the transfer of the glucuronosyl group from uridine 5'-diphospho-glucuronic acid (UDPGA) to substrate molecules that contain oxygen, nitrogen, sulfur or carboxyl functional groups. The resulting glucuronide is ionic, more polar, frequently more water soluble and less toxic, and is more easily excreted than the substrate molecule. The product is eliminated from the body by the kidneys.
Alternative names:
- glucuronyltransferase
[edit] Diseases
A deficiency of glucuronosyltransferase is thought to be the cause of Gilbert's syndrome, which is characterized by hyperbilirubinemia.
It is also associated with Crigler-Najjar syndrome.
