Glial fibrillary acidic protein
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glial fibrillary acidic protein
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| Identifiers | |
| Symbol(s) | GFAP |
| Entrez | 2670 |
| OMIM | 137780 |
| RefSeq | NM_002055 |
| UniProt | P14136 |
| Other data | |
| Locus | Chr. 17 q21 |
Glial fibrillary acidic protein or GFAP is a type III protein of the intermediate filament principally found in astrocytes in the central nervous system, but can also be found in Neurons and Leydig Cells. It has a role in the Cytoskeleton of the Astrocyte.
Increased expression of this protein is evident in different situations commonly referred to as "Astrocytic Activation".
It is related to vimentin and undergoes post-translational modification when the astrocytes are dying. Upon cell-death, the protein get citrullinated, which leads to protein unfolding and proteolytic degradation.
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