Dimercaptosuccinic acid
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Dimercaptosuccinic acid
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| Systematic (IUPAC) name | |
| 2,3-bis-sulfanylbutanedioic acid | |
| Identifiers | |
| CAS number | 304-55-2 |
| ATC code | ? |
| PubChem | 9354 |
| DrugBank | APRD01236 |
| Chemical data | |
| Formula | C4H6O4S2 |
| Mol. weight | 182.22 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | 48 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Dimercaptosuccinic acid, or DMSA, is a chelating agent. Its full chemical name is meso 2,3-dimecaptosuccinic acid.
DMSA is a white crystaline powder with an unpleasant but characteristic mercaptor odour and taste.
It is used to transfer mercury and other heavy metals safely into the urine for excretion. DMSA can cross the blood-brain barrier, and thus is useful for extracting heavy metals from the brain.[1]
DMSA is also called succimer, and is sold under the brand name Chemet®.
[edit] References
- ^ Aasath, Jan, Dag Jacobsen, Ole Andersen, Elsa Wickstrøm (March 1995). "Treatment of Mercury and Lead Poisonings with Dimercaptosuccinic Acid (DMSA) and Sodium Dimercaptopropanesulfonate (DMPS); also presented at the fifth Nordic Symposium on Trace Elements in Human Health and Disease, Loen, Norway, June 19-20, 1994.". Analyst 120: 853ff.
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