Coilin
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Coilin protein is one the main molecular components of Cajal bodies (CBs). Other than providing structural role, coilin acts as the glue to connect the CB to the nucleolus. When studying CBs, it is can be combined with GFP (Green Fluorescent Protein) to form Colin-GFP hybrid protein. Then the hybrid protein can be used to locate CBs underneath a microscope, usually near the nucleolus of the cell. Other proteins that make up the CB include snRNPs and nucleolar snoRNPs.
Coilin gets its name from the coiled shaped of the CB in which it is found.
It is was first identified using human autoimmune serum.
[edit] References
[1] Ogg, C. Stephen and Lamond, Angus I. Cajal bodies and coilin - moving towards function. Journal of Cell Biology, Voume 159, Number 1, October 14, 2002 17-21.
[2] http://redbone.umassmed.edu/nucleus.html
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