Talk:Cannabinoids

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in section "Cannabinoids",

the sentence on reversible binding and stereoselectivity should be explained in more lay terms

are all of these insoluble in water and soluble in fats, alcohols, etc?

in section "Herbal cannabinoids",

"21 carbon compounds": do you simply mean that they contain 21 carbon atoms?

Also, the chemical discussion here is written such that it might be general, abo ut all cannabinoids, not just the herbal ones. is this correct or not?

- Centrx 22:14, 25 May 2004 (UTC)

Contents 1 New antidepressant drug increases 'brain's own cannabis' 2 Deficiency? 3 THC synthesis pathway: reference needed 4 Percents and times 5 This article should be divided

[edit] New antidepressant drug increases 'brain's own cannabis'

http://www.eurekalert.org.nyud.net:8090/pub_releases/2005-12/mu-nad121305.php

Someone with more experience in this subject ought to add information regarding synthetic THC analogues. In particular, THC-V seems interesting because it is 500 times more potent than THC (on the order of LSD's potency). http://www.erowid.org/archive/rhodium/chemistry/thc/index.html

[edit] Deficiency?

I've heard some talk about "endo-cannabinoid deficiency" as a possible syndrome similar to chronic fatigue (or other symptoms, depending on whom you ask) ... Is this a real working medical hypothesis, or just some wishful thinking by potheads? Google doesn't turn up much on the subject, however that in itself doesn't mean it's not true... Rainman420 06:25, 13 May 2006 (UTC)

It is a real theory put forward by (presumably not pot-head) scientists. Here is a link to the abstract for a review paper in which cannabinoid deficiency syndrome is proposed: [[1]]. That said, it is still in an infant theory stage, and needs to be tested. Just as an FYI, a good place to look for information on this kind of thing (as long as it is biomedically related) is PubMed[[2]]. Hope this helps! --MudPhud 18:53, 14 July 2006 (UTC)

[edit] THC synthesis pathway: reference needed

The article currently states: " Due to molecular similarity and ease of synthetic conversion, it was originally believed that CBD was a natural precursor to THC. However, it is now known that CBD and THC are produced independently in the cannabis plant. "

Mahlberg and Kim (http://www.hempreport.com/issues/17/malbody17.html) state "Delta 9-tetrahydrocannabinol (THC) is derived from CBD." This is supported by the following reference: Lanyon, V., J. Turner and P. G. Mahlberg. 1981. Quantitative analysis of cannabinoids in the secretory product from capitate-stalked glands of Cannabis sativa L. (Cannabaceae). Bot. Gaz. 142:316-319.

Hillig and Mahlberg (2004 http://www.amjbot.org/cgi/content/full/91/6/966) state that "Cannabigerol (CBG) is the direct precursor of cannabichromene (CBC), cannabidiol (CBD), and 9-tetrahydrocannabinol (THC) (Taura et al., 1995 , 1996  ; Morimoto et al., 1997)." This does not explicitly state that CBD is never a precursor to THC. Perhaps the cited material does make that statement, but if that is the case, then it should be explained in the article, with appropriate citation. Chondrite 20:45, 6 August 2006 (UTC)

[edit] Percents and times

This article said that HU-210 is 100-800 times as powerful as THC. the HU-210 article says it's 100-800 percent more powerful! Which is it? I brought this article in line with the "main" one (i.e., HU-210), but couldn't find any confirmation one way or the other in independent sources. Then again, I'm not a biochemist. Anyone? --tgeller 05:10, 11 October 2006 (UTC)

[edit] This article should be divided

This article is too large. It mainly deals with natural compounds of the cannabis plant and many of the compounds mentioned in the Table of natural cannabinoids does not bind to the cannabinoid receptors. In the scientific literature the term cannabinoid includes all chemicals that bind to the cannabinoid receptors (natural and synthetic cannabinoids, cannabinoid agonists and antagonists, like rimonabant). Synthetic cannabinoids are much more potent than natural ones. Synthetic cannabinoids are important research tools and many of them have been shown to have therapetic potential and are in drug development, which makes them more interesting and important than natural cannabinoids. I suggest that this article will be divited into sections:

• Natural cannabinoids (of the cannabis plant)
• Synthetic cannabinoids
• Endocannabinoids

--Tanevala 15:28, 19 November 2006 (UTC)

Go for it, SqueakBox 18:15, 19 November 2006 (UTC)