Betamethasone

From Wikipedia, the free encyclopedia


Betamethasone
Systematic (IUPAC) name
9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16- trimethyl-6,7,8,9,10,11,12,13,14,15,16,17- dodecahydrocyclopenta[a]phenanthren-3-one
Identifiers
CAS number	378-44-9
ATC code	A07 EA04 C05 AA05 D07 AC01 D07 XC01 H02 AB01 R01 AD06 R03 BA04 S01 BA06 S01 CB04 S02 BA07 S03 BA03
PubChem	9782
DrugBank	APRD00513
Chemical data
Formula	C₂₂H₂₉F O₅
Mol. weight	392.461
Pharmacokinetic data
Bioavailability	?
Metabolism	hepatic CYP3A4
Half life	5.6 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	C(US)
Legal status	℞ Prescription only
Routes	oral or topical

Betamethasone is a moderate-potent glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities, used especially where water retention is undesirable. It is applied as a topical cream, ointment, lotion or gel to treat itching (e.g. from eczema).

It is available as a number of salts: Dipropionate (e.g. Diprosone®), Sodium Phosphate and Valerate (e.g. Betnovate®).

[edit] Indications

Corticosteroid used to stimulate fetal lung maturation and to decrease the incidence and mortality from intracranial hemorrhage in premature infants.

[edit] Fetal risk

As it crosses the placenta, which is required for its beneficial effects, it may also be associated with complications, such as hypoglycemia and leucocytosis in newborns exposed in utero.

[edit] External links

Betamethasone. safefetus.com.
Betamethasone. Pharmacy Services. Medical University of South Carolina.

Link page to external chemical sources.

Corticosteroids - glucocorticoid/receptor and mineralocorticoid/receptor edit (A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B)
Alclometasone, Aldosterone, Amcinonide, Beclometasone, Betamethasone, Budesonide, Ciclesonide, Clobetasol, Clobetasone, Clocortolone, Cloprednol, Cortisone, Cortivazol, Deflazacort, Deoxycorticosterone, Desonide, Desoximetasone, Desoxycortone, Dexamethasone, Diflorasone, Diflucortolone, Difluprednate, Fluclorolone, Fludrocortisone, Fludroxycortide, Flumetasone, Flunisolide, Fluocinolone acetonide, Fluocinonide, Fluocortin, Fluocortolone, Fluorometholone, Fluperolone, Fluprednidene, Fluticasone, Formocortal, Halcinonide, Halometasone, Hydrocortisone/cortisol, Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate, Loteprednol, Medrysone, Meprednisone, Methylprednisolone, Methylprednisolone aceponate, Mometasone furoate, Paramethasone, Prednicarbate, Prednisone/Prednisolone, Prednylidene, Rimexolone, Tixocortol, Triamcinolone, Ulobetasol