Atracurium
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Atracurium
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| Systematic (IUPAC) name | |
| 5-[3-[1-[(3,4-dimethoxyphenyl)methyl]- 6,7-dimethoxy-2-methyl-3, 4-dihydro-1H-isoquinolin-
2-yl] propanoyloxy] pentyl 3-[1-[(3,4-dimethoxyphenyl)methyl]- 6,7-dimethoxy-2-methyl- 3,4-dihydro-1H-isoquinolin-2-yl] propanoate |
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| Identifiers | |
| CAS number | 64228-79-1 |
| ATC code | M03AC04 |
| PubChem | 9751 |
| DrugBank | APRD00806 |
| Chemical data | |
| Formula | C53H72N2O122+ |
| Mol. weight | 929.145 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 100% (IV) |
| Protein binding | 82% |
| Metabolism | Hoffman degradation and ester hydrolysis |
| Half life | 17-21 minutes |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
POM (UK) |
| Routes | IV |
Atracurium is a neuromuscular-blocking drug or muscle relaxant in the category non-depolarising neuromuscular blocking agents, used in anaesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
Side effects due to histamine liberation are rash, increase of heartrate, low blood pressure and bronchospasm.
It is a bisbenzylisoquinoliniumand a mix of 10 Stereoisomers. First described by John B. Stenlake.
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| Muscle relaxants (M03) edit | ||
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| Peripherally acting: |
Alcuronium, Atracurium, Cisatracurium, Dimethyltubocurarine, Doxacurium chloride, Fazadinium bromide, Gallamine, Hexafluronium, Mivacurium chloride, Pancuronium, Pipecuronium bromide, Rocuronium bromide, Suxamethonium, Tubocurarine, Vecuronium |
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| Centrally acting: |
Baclofen, Carisoprodol, Chlormezanone, Chlorzoxazone, Cyclobenzaprine, Febarbamate, Mephenesin, Methocarbamol, Orphenadrine, Phenprobamate, Phenyramidol, Pridinol, Styramate, Tetrazepam, Thiocolchicoside, Tizanidine, Tolperisone |
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| Directly acting: | ||
