| 18 km |
Crosses Highway 660 |
54°17′48.82″N, 110°45′19.92″W |
| 20 km |
Enters the town of Bonnyville and becomes 55th Street and crosses Highway 28 |
54°16′29.43″N, 110°44′31.46″W |
| 30 km |
Passes by Muriel Lake near the hamlet of Gurneyville and goes west |
|
| 35 km |
Crosses Highway 657 as it enters the Kehewin Indian Reserve 123 |
54°07′32.34″N, 110°47′22.58″W |
| 43 km |
Meets and joins Highway 28 and goes south |
54°06′41.06″N, 110°53′28.59″W |
| 55 km |
Highway 28 leaves toward the west |
53°58′34.38″N, 110°53′49.94″W |
| 64 km |
Enters the town of Elk Point where it crosses Highway 646 |
53°53′20.99″N, 110°53′45.94″W |
| 79 km |
Highway 640 branches off to the east |
53°44′38.18″N, 110°53′45.71″W |
| 91 km |
Highway 45 branches off to the west leading to the village of Derwent |
53°39′24.98″N, 110°52′06.36″W |
| 98 km |
Highway 45 branches off to the east |
53°35′56.25″N, 110°52′00.07″W |
| 105 km |
Highway 631 branches off to the west |
53°32′25.47″N, 110°52′01.23″W |
| 127 km |
Passes through the town of Vermilion and crosses Highway 16 |
53°20′14.87″N, 110°51′35.90″W |
| 150 km |
Crosses Highway 619 |
53°09′39.46″N, 110°52′59.09″W |
| 172 km |
Highway 883 branches off to the west |
53°59′54.92″N, 110°51′58.73″W |
| 178 km |
Highway 614 branches off to the east |
52°57′33.40″N, 110°49′29.60″W |
| 184 km |
Crosses Highway 14 east of the town of Wainwright |
52°50′35.49″N, 110°49′32.90″W |
| 224 km |
Crosses Highway 13 |
52°29′17.59″N, 110°49′10.39″W |
| 227 km |
Passes by the entrance to the village of Czar |
52°27′07.99″N, 110°49′01.16″W |
| 245 km |
Highway 600 branches off to the east |
52°19′03.05″N, 110°49′06.43″W |
| 254 km |
Highway 599 branches off to the west |
52°13′48.88″N, 110°50′13.72″W |
| 283 km |
Joins Highway 12 at the village of Consort and goes east while (Highway 886 branches to the south) |
52°00′04.78″N, 110°47′25.95″W |
| 300 km |
Branches off Highway 12 to the south |
51°59′22.90″N, 110°31′46.13″W |
| 368 km |
Reaches Highway 9 |
51°23′12.02″N, 110°28′23.76″W |
| 370 km |
Passes through the town of Oyen where Highway 895 branches to the south and Highway 41 turns to the southeast |
51°26′33.06″N, 110°45′42.19″W |
| 388 km |
Crosses Highway 570 |
51°14′26.04″N, 110°14′12.84″W |
| 397 km |
Passes by the hamlet of Acadia Valley |
51°09′12.92″N, 110°13′14.49″W |
| 418 km |
Highway 562 branches off to the east |
50°58′42.21″N, 110°11′36.98″W |
| 424 km |
Crosses the Red Deer River |
50°55′59.13″N, 110°08′58.77″W |
| 427 km |
Highway 899 branches off to the east |
50°54′18.36″N, 110°07′33.29″W |
| 430 km |
Highway 555 branches off to the west |
50°51′45.03″N, 110°07′10.54″W |
| 445 km |
Crosses the South Saskatchewan River |
50°43′06.56″N, 110°04′42.67″W |
| 454 km |
Highway 545 branches off to the east |
50°39′31.25″N, 110°05′45.62″W |
| 481 km |
Highway 537 branches off to the east |
50°25′30.55″N, 110°05′44.84″W |
| 498 km |
Highway 528 branches off to the east |
50°15′02.74″N, 110°16′45.63″W |
| 550 km |
Highway 41A branches off to the west |
50°01′47.57″N, 110°32′00.56″W |
| 556 km |
Joins Highway 1 east of the city of Medicine Hat and goes east |
49°58′28.38″N, 110°33′04.62″W |
| 572 km |
Leaves Highway 1 to the south |
49°57′19.67″N, 110°20′22.49″W |
| 590 km |
Highway 515 branches off to the east |
49°47′11.53″N, 110°20′33.57″W |
| 602 km |
Highway 514 branches off to the west |
49°41′12.41″N, 110°17′51.93″W |
| 604 km |
Passes through Elkwater and the Cypress Hills Interprovincial Park |
49°39′58.60″N, 110°16′17.30″W |
| 662 km |
Crosses Highway 501 |
49°14′40.73″N, 110°15′02.89″W |
| 686 km |
Reaches the United States border at the hamlet of Wild Horse where it ends |
49°00′00″N, 110°12′55.61″W |
