4-Methylbenzylidene camphor
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| 4-MBC | |
|---|---|
| Chemical name | 4-Methylbenzylidene camphor (4-MBC) |
| Chemical formula | C18H22O |
| Molecular mass | 254.4 |
| Melting point | 66-70°C |
| Boiling point | |
| Density | |
| CAS number | 36861-47-9 |
| SMILES | |
4-Methylbenzylidene camphor, short 4-MBC, also 3-(4-Methylbenzylidene)bornan-2-one, or 3-(4-Methylbenzylidene)-dl-camphor is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation. As such it is used in sunscreen lotions and deodorants. Its tradename is Eusolex® 6300.
Contents |
[edit] Endocrine disruptor
Studies have raised the issue that 4-MBC acts an endocrine disruptor. There is controversy about the estrogenic effects of 4-MBC and while one study showed only a relatively minor effect[1], a study in Switzerland showed significant uterine growth in immature rodents.[2] In addition, there is some evidence that 4-MBC may suppress the pituitary-thyroid axis leading to hypothyroidism.[3]
The agent can also lead to a photoallergic dermatitis.
[edit] Approval status
4-MBC is approved for use in Europe by the European Union's Scientific Committee for Cosmetic Products & Non-Food Products but is not approved for use in the USA by the Food and Drug Administration.
[edit] Alternative agents
Alternative agents that block UV by absorption include:
- Avobenzone
- Oxybenzone
- octyl methoxycinnamate (OMC)
- benzophenone-3
- butyl methoxydibenzoylmethane
- homosalate
[edit] See also
[edit] References
- ^ [1] Low estrogenic activity
- ^ [2] Significant estrogenic activity
- ^ [3] Inhibition of pit-thyroid axis
