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Immagine:Ubiquitin specific activation.png

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Description

Ubiquitin links specific protein to be degraded. E1 protein (PDB code=1r4n) activates ubiquitin (shown in orange, with ATP in red). E1 passes ubiquitin to several specific E2 proteins (1fxt), that link ubiquitin through a cysteine (shown in yellow). E2 associates with specific E3 proteins (1ldk, 1fqv) that bind together the activated ubiquitin and the protein to be degraded (teh exact site is starred) (more details...)

Source

Molecule of the Month by www.pdb.org (see the Molecule of the Month section for more details]

Date

Year 2004 (see the complete list for more details)

Author

Illustration by David S. Goodsell of The Scripps Research Institute (see this site)

Permission

Original work of the US Federal Government - public domain

Public domain This work is in the public domain in the United States because it is a work of the United States Federal Government under the terms of Title 17, Chapter 1, Section 105 of the US Code. See Copyright.

Note: This only applies to works of the Federal Government and not to the work of any individual U.S. state, territory, commonwealth, county, municipality, or any other subdivision.


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