Insulin pump

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Insulin Pump with an Infusion Set

An insulin pump is a medical device used for administering insulin in the treatment of diabetes mellitus. The device includes:

the pump itself (including controls, processing module, and batteries)
a disposable reservoir for insulin (inside the pump)
a disposable infusion set, including a cannula for subcutaneuos insertion (under the skin) and a tubing system to interface the insulin reservoir to the cannula.

An insulin pump is an alternative to multiple daily injections of insulin by syringe or an insulin pen and allows for intensive insulin therapy when used in conjunction with blood glucose monitoring and carb counting.

1 Dosing
2 Advantages
3 Disadvantages
4 Acceptability
5 Recent developments
6 Current insulin pump manufacturers
7 Future developments
8 Bibliography
9 External links

[edit] Dosing

Insulin pump therapy, also known as continuous subcutaneous insulin infusion, allows the pump user to replace the use of slow-acting insulin for basal insulin needs with a continuous infusion of rapid-acting insulin.

The insulin pump delivers a single type of fast-acting insulin in two ways:

a bolus dose that is pumped to cover food eaten or to correct a high blood glucose level.
a basal dose that is pumped continuously at an adjustable basal rate to deliver insulin needed between meals and at night.

[edit] Bolus Shaping

An insulin pump user has the ability to influence the profile of the rapid-acting insulin by shaping the bolus. While each user must experiment with bolus shapes to determine what is best for any given food, they can improve control of blood sugar by adapting the bolus shape to their needs.

A standard bolus is an infusion of insulin pumped completely at the onset of the bolus. It is most similar to an injection. By pumping with a "spike" shape, the expected action of insulin is the fastest possible for that type of insulin. The standard bolus is most appropriate when eating high carb low protein low fat meals because it will return blood sugar to normal levels as fast as possible.

An extended bolus is a slow infusion of insulin spread out over time. By pumping with a "square wave" shape, the bolus avoids a high initial dose of insulin that may enter the blood and cause low blood sugar before digestion can facilitate sugar entering the blood. The extended bolus also extends the action of insulin well beyond that of the insulin alone. The extended bolus is appropriate when covering high fat high protein meals such as steak, which will be raising blood sugar for many hours past the onset of the bolus. The extended bolus is also useful for those with slow digestion (such as with Celiac disease).

A combination bolus is the combination of a standard bolus spike with an extended bolus square wave. This shape provides a large dose of insulin up front, and then also extends the tail of the insulin action. The combination bolus is appropriate for high carb high fat meals such as pizza, pasta with heavy cream sauce, and chocolate cake.

A super bolus is a method of increasing the spike of the standard bolus. Since the action of the bolus insulin will be for several hours, the basal insulin could be stopped or reduced during this time. This facilitates the "borrowing" of the basal insulin and including it into the bolus spike to deliver the same total insulin with faster action than spike plus basal rate.

[edit] Basal Rate Patterns

The pattern for delivering basal insulin throughout the day can also be customized with a pattern to suit the pump user.

A reduction of basal at night to prevent low blood sugar.
A pre-dawn increase to prevent high blood sugar due to the dawn effect.
In a proactive plan before exercise times.

[edit] Temporary Basal Rates

Since the basal insulin is provided as a rapid-acting insulin, the basal insulin can be immediately increased or decreased as needed with a temporary basal rate. Examples when this is helpful include:

During illness or stress, when basal demand increases due to insulin resistance.
During a long car drive, when more insulin is needed due to inactivity.
During and after exercise, when the body needs less insulin.

[edit] Advantages

The use of rapid-acting insulin for basal needs offers relative freedom from a structured meal and exercise regimen previously needed to control blood sugar with slow-acting insulin.
Many pumpers feel that bolusing insulin from a pump is more convenient and discrete compared to injection.
Insulin pumps also make it possible to deliver more precise amounts of insulin than can be injected using a syringe. This supports tighter control over blood sugar and Hemoglobin A1c levels, reducing the chance of long-term complications associated with diabetes. This is predicted to result in a long term cost savings relative to multiple daily injections.[1]

[edit] Disadvantages

Insulin pumps, cartridges, and infusion sets are more expensive than syringes used for insulin injection.
Since the insulin pump needs to be worn most of the time, pump users need strategies to participate in activities that may damage the pump, such as rough sports and activities in the water. Some users may find that wearing the pump all the time (together with the infusion set tubing) is uncomfortable or unwieldy.
A disadvantage of giving up slow-acting insulin is that the user may suffer an episode of diabetic ketoacidosis if the pump user does not receive sufficient fast acting insulin for many hours. This can happen if the pump battery is discharged, or if the insulin runs empty, or the tubing becomes loose and insulin leaks rather than being injected. Therefore pump users typically monitor their blood sugars more frequently to evaluate the effectiveness of insulin delivery, and this should safeguard against occurrences of ketoacidosis.

[edit] Acceptability

Use of insulin pumps is increasing throughout the world because:

it provides an easier means to deliver multiple insulin injections for those using intensive insulin therapy. This is especially true for children and others who are uncomfortable with needles (although the pump user still has to inject an infusion set every few days, and poke fingers for blood glucose tests many time a day).
acceptance among doctors and insurance companies due to the benefits contributing to reducing the incidence of long-term complications. It's also interesting to note that because of differences in health insurance and public funding, the US has about 150,000 pump users. In the UK, NICE have now ruled that if a diabetic patient's doctor agrees that they should be using an insulin pump, they should apply to the NHS and they will fund it. Therefore numbers are increasing but are still less than the USA, there are around 1100 pump users in the UK by comparison.
improvements in blood glucose monitoring. New meters require smaller drops of blood, and the corresponding lancet poke in the fingers is smaller and less painful. These meters also support alternate site testing for the most routine tests for practically painless testing. This compensates for the need for pump users to test blood sugar more frequently.
techniques learned to adapt their pump use to sports, exercise, and water sports. Expert help is becoming common in user groups and books. The pump can be effectively combined with partial basal insulin from the pump and partial basal insulin from a long-acting insulin such as Lantus and Levemir. This is becoming known as the Untethered Regemin.

[edit] Recent developments

New insulin pumps are becoming "smart" as new features are added to their design. These simplify the tasks involved in delivering an insulin bolus.

insulin on board: Based on the time and quantity of the last bolus, the pump software keeps track of the insulin remaining in the bloodstream and displays it on the screen. This supports the process of performing a new bolus before the effects of the last bolus are complete, and thereby helps prevent the user from overcompensating for high blood sugar with unnecessary correction boluses.
bolus wizards: Pump software helps by calculating the dose for the next insulin bolus. The user enters the grams of carbohydrates to be consumed, and the bolus wizard calculates the number of units of insulin needed. It adjusts for the most recent blood glucose level and the insulin on board, and then suggests the best insulin dose to the user to approve and bolus.
custom alarms: The pump can monitor for activities during specific times of day and then alarm the user if an expected activity did not occur. Examples include a missed lunch bolus, a missed blood glucose test at 10am, a new blood glucose test 15 minutes after a low blood glucose test, etc. The alarms can be customized to support each user.
touch bolus: For persons with visual impairments, this button on the pump can be used to bolus for insulin without using the display. This works with a system of beeps to confirm the bolus parameters to the pump user.
interface to personal computers: New pumps interface to personal computers for managing and documenting pumps delivery programs and to upload data from the pump. This simplifies record keeping and can be interfaced with diabetes management software.
integration with blood glucose meters: Blood glucose data can be manually entered into the pump for supporting the bolus wizard for calculation of the next insulin bolus. Some pumps are supporting an interface from the insulin pump to a blood glucose meter.
- The Cozmo pump works with the CozMonitor (using Freestyle test strips) attached to the back of the pump. The pump receives glucose readings from this attached meter via infrared (IR).
- The Medtronic Minimed Paradigm 512 insulin pump allows for radio frequency (RF) communication to the pump. This was previously used to read blood glucose data from a blood glucose meter called the Paradigm Link, and now can interface with a continuous blood glucose sensor.
- The Insulet Myomnipod has a separate electronic display with a built-in meter that uses Freestyle test strips.
A remote control: allows a discrete bolus when the pump is concealed or inaccessible.
tubeless pod: one pump can be attached directly to the skin by its infusion set, eliminating the tube from the pump.

[edit] Current insulin pump manufacturers

[edit] Future developments

When insulin pump technology is combined with a continuous blood glucose monitoring system, the technology seems promising for real-time control of the blood sugar level. Currently there are no mature algorithms to automatically control the insulin delivery based on feedback of the blood glucose level. When the loop is closed, the system may function as an artificial pancreas.
Insulin pumps are being used for infusing pramlintide (brand name Simlin, or synthetic amylin) with insulin for improved post-prandial glycemic control compared to insulin alone.
An insulin pump that can be surgically implanted inside the body will be available soon by Medtronic. It is the approximate size of a hockey puck, and communicates via RF to an external control. It is refilled by injection through the skin, and holds approximately 2 weeks of insulin.

[edit] Bibliography

[edit] External links

Retrieved from "http://en.wikipedia.org../../../i/n/s/Insulin_pump.html"

Categories: Medical pumps | Insulin therapies | Diabetes

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