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锌指结构 - Wikipedia

锌指结构

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锌指结构指的是在很多蛋白中存在的一类具有指状结构的结构域,这些具有锌指结构的蛋白大多都是与基因表达的调控有关的功能蛋白。

锌指结构的共同特征是通过肽链中氨基酸残基的特征集团与Zn2+的结合来稳定一种很短的,可自我折叠成“手指”形状的的多肽空间构型。

锌指蛋白最初在非洲爪蟾的卵母细胞中发现,已知广泛分布在动物植物微生物中,人类基因组中可能有将近1%的序列编码的是含有锌指结构的蛋白质,目前人们已经清楚地知道锌指结构是识别特定碱基序列的一种普遍性的转录因子结构,但大多数含有锌指结构蛋白质的确切功能以及他们是否具有其他方面的功能尚不清楚。

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