Doxazosin
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Doxazosin
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| Systematic (IUPAC) name | |
| [4-(4-amino-6,7-dimethoxy- quinazolin-2-yl) piperazin-1-yl]- (2,5-dioxabicyclo[4.4.0] deca-6,8,10-trien-4-yl) methanone | |
| Identifiers | |
| CAS number | 74191-85-8 |
| ATC code | C02CA04 |
| PubChem | 3157 |
| DrugBank | APRD00474 |
| Chemical data | |
| Formula | C23H25N5O5 |
| Mol. weight | 451.475 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 65% |
| Protein binding | 98% |
| Metabolism | Hepatic |
| Half life | 22 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
℞ Prescription only |
| Routes | oral |
Doxazosin mesylate, a quinazoline compound sold by Pfizer under the brand name Cardura®, is an alpha blocker used to treat high blood pressure and benign prostatic hyperplasia. It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.
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| Antihypertensives (C02) and diuretics (C03) edit | ||
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| Antiadrenergic agents (including alpha): |
Clonidine, Doxazosin, Guanethidine, Guanfacine, Lofexidine, Mecamylamine, Methyldopa, Moxonidine, Prazosin, Rescinnamine, Reserpine |
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| Vasodilators: |
Diazoxide, Hydralazine, Minoxidil, Nitroprusside, Phentolamine |
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| Other antihypertensives: | ||
| Low ceiling diuretics: |
Bendroflumethiazide, Chlorothiazide, Chlortalidone, Hydrochlorothiazide, Indapamide, Quinethazone, Mersalyl, Metolazone, Theobromine |
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| High ceiling diuretics: | ||
| Potassium-sparing diuretics: | ||
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