2C-T-7

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2C-T-7
Chemical name	2-[2,5-dimethoxy-4-(propylthio)phenyl]ethanamine
Chemical formula	C₁₃H₂₁NO₂S
Molecular mass	255.3799
Melting point	?
CAS numbers	207740-26-9
SMILES	COc1cc(SCCC)c(cc1CCN)OC

2C-T-7 is a psychedelic phenethylamine and is sometimes used as an entheogen. It was presumably first synthesized in 1986 by Alexander Shulgin. It has structural and pharmacodynamic properties similar to the drugs Mescaline, MDMA, 2C-T-2 and 4-MTA. An often used slang term for 2C-T-7 is "watusi".

1 Chemistry
2 Pharmacology
3 Recreational usage
4 Legality
5 References
6 See also
7 External links

[edit] Chemistry

2C-T-7 is 4-(n)-propyl thio-2,5-dimethoxy phenethylamine with the formula C₁₃H₂₁O₂N S. The full name of the chemical is 2-[2,5-dimethoxy-4-(propylthio)phenyl]ethanamine.

[edit] Pharmacology

2C-T-7 is a hallucinogenic phenethylamine. In his book PIHKAL (Phenethylamines I Have Known and Loved), Shulgin lists the dosage range as 10-30mg. 2C-T-7 is generally taken orally, and produces psychedelic and entheogenic effects that last 8 to 12 hours.

The mechanism that produces the hallucinogenic and entheogenic effects of 2C-T-7 is most likely to result from action as a 5-HT_2A serotonin receptor agonist in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines.^[1]

2C-T-7 also has a separate action as a selective monoamine oxidase A inhibitor. This makes 2C-T-7 a potentially dangerous drug as at high doses it can slow down the degradation of serotonin in the brain, which can lead to serotonin syndrome and potential death without treatment.^[2]</ref>

Several of the deaths involving 2C-T-7 followed co-administration of the drug with other stimulants such as MDMA and Ephedrine, and so these kind of combinations should be avoided.

[edit] Recreational usage

2C-T-7 has been sold on the street under the names "Blue Mystic," "Tweetybird Mescaline," "7th Heaven," and "Lucky 7." The drug can be taken orally or snorted, and can be lethal even in small doses.^[3]

Around the year 2000, 2C-T-7 began to change from an obscure chemical to a drug used at parties and clubs in North America and Europe as it became available through a number of grey-market commercial vendors.

There have been at least three reported deaths related to 2C-T-7 use, mainly at high doses of 30mg or more or combined with stimulants ^[4], as well as a number of very bad trips and hospitalizations ^[5], these mostly followed "snorting" of 2C-T-7. In January of 2002, Rolling Stone published an article about 2C-T-7 entitled "The New (legal) Killer Drug". It can cause nausea and may be dangerous when combined with alcohol.

Use of 2C-T-7 as a nootropic at low doses of 1mg has been reported, and it may be useful for this purpose in a similar manner to LSD, which shows modest stimulant and nootropic effects at doses of 10μg.

[edit] Legality

On September 20, 2002, 2C-T-7 was classified as a Schedule I substance in the United States by an emergency ruling by the DEA.

[edit] References

^ Fantegrossi, WE, Harrington AW, Eckler JR, Arshad S, Rabin RA, Winter JC, Coop A, Rice KC, Woods JH (September 2005). "Hallucinogen-like actions of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) in mice and rats.". Psychopharmacology (Berlin) 181 (3): 496-503.
^ Gallardo-Godoy, A, Fierro A, McLean TH, Castillo M, Cassels BK, Reyes-Parada M, Nichols DE. (April 7, 2005). "Sulfur-substituted alpha-alkyl phenethylamines as selective and reversible MAO-A inhibitors: biological activities, CoMFA analysis, and active site modeling.". Journal of Medicinal Chemistry 48 (7): 2407-19.
^ Partnership for a Drug-Free America. 2C-B, 2C-T-7. Retrieved on 2006-10-04.
^ Erowid. Third Confirmed 2C-T-7 Death. Retrieved on 2006-12-06.
^ Erowid. 2C-T-7 Reports Train Wrecks & Disasters. Retrieved on 2006-12-06.

[edit] See also

Hallucinogenic phenethylamines edit
2C-B, 2C-B-FLY, 2C-C, 2C-D, 2C-E, 2C-G, 2C-I, 2C-N, 2C-O, 2C-O-4, 2C-P, 2C-T, 2C-T-2, 2C-T-4, 2C-T-7, 2C-T-8, 2C-T-9, 2C-T-21, 2C-TFM, 3C-E, 3C-P, Br-DFLY, DESOXY, DMMDA-2, DOB, DOC, DOET, DOI, DOM, DON, Escaline, Isoproscaline, Lophophine, MDA, MMDA, Macromerine, Mescaline, Proscaline, TMA