Choriocarcinoma

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Choriocarcinoma
Classifications and  external resources
ICD-9 181
ICD-O: 9100-9101

Choriocarcinoma is  a malignant and  aggressive cancer of the placenta. it  is characterized by early hematogenous spread to the lungs. it  belongs to the far end of the spectrum of Gestational Trophoblastic Diseases (GTD). Broadly, GTDs can be classified in the following:

1. Hydatidiform Mole

  a. Complete Mole
  b. Partial Mole

2. Invasive Mole 3. Choriocarcinoma

  a. Limited to the uterus
  b. Metastatic

Contents

[edit] Etiology/Epidemiology

It is  preceded by

[edit] Symptoms/Signs/Labs

  • increased quantitative β-hCG levels
  • vaginal bleeding
  • shortness of breath
  • hemoptysis (coughing up blood)
  • chest pain
  • chest X-ray shows multiple infiltrates of various shapes in both lungs
  • presents in males as a testicular neoplasm

[edit] Pathology

On light microscopy, there is  malignant trophoblastic proliferation without hydropic villi.

[edit] Treatment

Choriocarcinoma is  one of the tumors that is  most sensitive to chemotherapy. The cure rate, even for metastatic choriocarcinoma, is  around 90-95%. Virtually everyone without metastases can be cured. Chemotherapy regimen include EMACO (etoposide, methotrexate, actinomycin D, cyclosphosphamide and  oncovin).

Hysterectomy (surgical removal of the uterus) can also be offered to patients > 40 years of age or  those desiring sterilization. it  may be required for those with severe infection and  uncontrolled bleeding.


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