Restless legs syndrome

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**Restless legs syndrome**
*Classifications and external resources*
ICD-10	G 25.8
ICD-9	333.99
OMIM	102300 608831
DiseasesDB	29476
eMedicine	neuro/509
MeSH	D012148

Restless legs syndrome (RLS, or Wittmaack-Ekbom's syndrome) is a poorly understood and often misdiagnosed neurological disorder. It is sometimes simply called "Ekbom's syndrome", but care should be used when using that term, because there is a distinct condition which shares that same eponym: delusional parasitosis.

RLS (which is also sometimes referred to as Jimmy Legs, spare legs or "the kicks") may be described as uncontrollable urges to move the limbs in order to stop uncomfortable, painful or odd sensations in the body, most commonly in the legs. Moving the affected body part eliminates the sensation, providing temporary relief. The sensations and need to move may return immediately after ceasing movement, or at a later time. RLS may start at any age, including early childhood, and is a progressive disease for a certain percentage of sufferers, although it has been known for the symptoms to disappear permanently in some sufferers.

1 Symptoms
- 1.1 NIH criteria
2 Incidence/Prevalence
3 History
4 Types
5 Causes
- 5.1 Genetics
6 Treatment
7 See also
8 External links
9 References
10 Sources

[edit] Symptoms

"An urge to move, usually due to uncomfortable sensations that occur primarily in the legs."

The sensations are unusual and unlike other common sensations, and those with RLS have a hard time describing them. People use words such as: uncomfortable, electrical, creeping, painful, itching, pins and needles, pulling, creepy-crawly, ants inside the legs, and many others. The sensation and the urge can occur in any body part; the most cited location is legs, followed by arms. Some people have little or no sensation, yet still have a strong urge to move.

"Motor restlessness, expressed as activity, that relieves the urge to move."

Movement will usually bring immediate – however often temporary – relief. Walking is most common; however, doing stretches, yoga, biking, or other physical activity may relieve the symptoms. Constant and fast up-and-down movement of the leg, coined "sewing machine legs" by at least one RLS sufferer, is often done to keep the sensations at bay without having to walk. Sometimes a specific type of movement will help a person more than another.

"Worsening of symptoms by relaxation."

Any type of inactivity involving sitting or lying – reading a book, a plane ride, watching TV or a movie, taking a nap - can trigger the sensations and urge to move. This depends on several factors: the severity of the person’s RLS, the degree of restfulness, the duration of the inactivity, etc.

"Variability over the course of the day-night cycle, with symptoms worse in the evening and early in the night."

While some people only experience RLS at bedtime and others experience it all day and all night, all sufferers notice that the RLS is worst in the evening and the least noticeable sometime in the early to mid morning.

[edit] NIH criteria

In 2003 National Institutes of Health (NIH) consensus panel modified their criteria in to include the following:

(1) an urge to move the limbs with or without sensations
(2) worsening at rest
(3) improvement with activity
(4) worsening in the evening or night.^[1]

[edit] Incidence/Prevalence

Restless Leg Syndrome plagues an estimated 2.7% of the general population in the U.S.A..^[2]

Often sufferers think they are the only ones to be afflicted by this peculiar condition and are relieved when they find out that many others also suffer from it. The severity and frequency of the disorder vary tremendously. Many people only experience symptoms when they try to sleep, while other experience symptoms during the day. It is common to have symptoms on long car rides or during any long period of inactivity (like watching television or a movie, attending a musical or theatrical performance, etc.) Approximately 80-90% of people with RLS also have PLMD, Periodic Limb Movement Disorder, which causes slow "jerks" or flexions of the affected body part. These occur during sleep (PLMS = Periodic Limb Movement while Sleeping) or while awake (PLMW - Periodic Limb Movement while Waking).

About 10 percent of adults in North America and Europe may experience RLS symptoms, according to the National Sleep Foundation, which reports that "lower prevalence has been found in India, Japan and Singapore," indicating that ethnic factors, including diet, may play a role in the prevalence of this syndrome. ^[3]

[edit] History

The Restless legs syndrome is also known as the Ekbom syndrome, the Wittmaack-Ekbom syndrome, or anxietas tibialis.

In a 1945 publication titled 'Restless Legs', Karl-Axel Ekbom described the disease and presented eight cases used for his studies.^[4]

Earlier studies were done by Thomas Willis (1622-1675) and by Theodor Wittmaack. Another early description of the disease and its symptoms were made by George Miller Beard (1839-1883).

[edit] Types

RLS is either primary or secondary.

Primary RLS is considered idiopathic, or with no known cause. Primary RLS usually begins before age 40 or 45, and can even occur as early as the first year of life. In primary RLS, the onset is often slow. The RLS may disappear for months, or even years. It is often progressive and gets worse as the person ages. RLS in children is often misdiagnosed as growing pains.

Secondary RLS often had a sudden onset and may be daily from the very beginning. It often occurs after the age of 40, however it can occur earlier. It is most associated with specific medical conditions or the use of certain drugs. The most commonly associated medical condition is iron deficiency, which accounts for just over 20% of all cases of RLS. The conditions include: pregnancy, varicose vein, folate deficiency, uremia, diabetes, thyroid problems, peripheral neuropathy, Parkinson's disease and certain auto-immune disorders such as Sjögren's syndrome, Celiac Disease, and rheumatoid arthritis. Treatment of the underlying condition often eliminates the RLS.

[edit] Causes

Certain medications may worsen RLS in those who already have it, or cause it secondarily. These include: anti-nausea drugs, certain antihistamines (often in over-the-counter cold medications), drugs used to treat depression (both older tricyclics and newer SSRIs), antipsychotic drugs, and certain medications used to control seizures. Some people find it is worsened by caffeine.

Both primary and secondary RLS can be worsened by surgery of any kind, however back surgery or injury is often associated with causing RLS. RLS often worsens in pregnancy.

[edit] Genetics

40% of cases of RLS are familial and are inherited in an autosomal dominant fashion with variable penetrance.

No one knows the exact cause of RLS at present. Research and brain autopsies have implicated both dopaminergic system and iron insufficiency in the substantia nigra (study published in Neurology, 2003)^[5]. Iron is an essential cofactor for the formation of L-dopa, the precursor of dopamine. An Icelandic study in 2005 confirmed the presence of an RLS susceptibility gene also found previously in a smaller French-Canadian population.^[6]^[7]

[edit] Treatment

An algorithm for treating RLS was created by leading RLS researchers at the Mayo Clinic and is endorsed by the Restless Legs Syndrome Foundation. This document provides guidance to both the treating physician and the patient, and includes both nonpharmacological and pharmacological treatments.^[8]

[edit] Iron supplements

All people with RLS should have their ferritin levels tested; ferritin levels should be at least 50 mcg for those with RLS. Oral iron supplements, taken under a doctor's care, can increase ferritin levels. For some people, increasing ferritin will eliminate or reduce RLS symptoms. However, at least 40% of people will not notice any improvement. IV iron is being tested at the US Mayo Clinic and John Hopkins Hospital as a method of treating RLS. It is dangerous to take iron supplements without first having ferritin levels tested, as many people with RLS do not have low ferritin and excess iron in the body can exacerbate hemochromatosis, a very dangerous condition.

[edit] Lifestyle changes and other non-medicinal approaches

Treatment for RLS is based on how disruptive the symptoms are. All people should review their lifestyle and see what changes could be made to reduce or eliminate their RLS symptoms. These include: finding the right level of exercise (too much worsens it, too little may trigger it); eliminating caffeine, smoking, and alcohol; changing the diet to eliminate foods that trigger RLS (different for each person, but may include eliminating sugar, triglycerides, gluten, sugar substitutes, following a low-fat diet, etc.); keeping good sleep hygiene; treating conditions that may cause secondary RLS; avoiding or stopping OTC or prescription drugs that trigger RLS; adding supplements such as magnesium, B-12, folate, vitamin E, and calcium. Some of these changes, such as diet and adding supplements are based on anecdotal evidence from RLS sufferers, as few studies have been done on these alternatives.

For those who experience RLS infrequently and do not need or want to try medication, in addition to lifestyle changes they can try:

some form of exercise for several minutes such as walking, stretching, yoga, etc. at bedtime
heat or cold, such as a hot or cold bath, a heating pad, or a fan
engrossing the mind into a game, the computer, or figuring something out
wearing compression stockings, tight pantyhose, or wrapping the legs in ace bandages
placing a pillow between the knees or upper-legs while laying in bed

[edit] Medicinal approaches

For those whose RLS disrupts or prevents sleep or regular daily activities, medication is often required. Many Doctors currently use, and the Mayo Clinic Algorithm includes, medication from four categories:

Dopamine agonists such as ropinirole, pramipexole, carbidopa/levodopa or pergolide
- In 2005, The Food and Drug Administration approved ropinirole to treat moderate to severe Restless Legs Syndrome (RLS). The drug was first approved for Parkinson's disease in 1997.
- In February 2006, the EU Scientific Committee issued a positive recommendation for approving pramipexole (Mirapex, Sifrol, Mirapexen in the EU) for the treatment of RLS in the EU. US FDA approval is expected sometime in 2006.
- Another dopamine agonist, rotigotine delivered via a transdermal patch, is currently in process for US FDA and EU approval for RLS.
- Dopamine agonists may cause augmentation. This is a medical condition where the drug itself causes symptoms to increase in severity and/or occur earlier in the day. Dopamine agonists may also cause rebound, when symptoms increase as the drug wears off.
Opioids such as propoxyphene, oxycodone, or methadone
Benzodiazepines, which often assist in staying asleep and reducing awakenings from the movements
Anticonvulsants, which often help people who experience the RLS sensations as painful, such as gabapentin

Other medicinal approaches include the following:

There is also strong anecdotal evidence that medical marijuana alleviates RLS, although studies are lacking because of governmental restrictions.^{[citation needed]}

Some people have reported partial or even complete relief with taking a supplemental magnesium salt such as magnesium oxide or magnesium gluconate once or twice a day, backing off on the dose if diarrhea develops. Magnesium sulfate is the most active form. However anyone with renal problems should stay away from magnesium supplements.

[edit] See also

Actigraphy

[edit] External links

[edit] References

^ Allen R, Picchietti D, Hening W, Trenkwalder C, Walters A, Montplaisi J (2003). "Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health.". Sleep Med 4 (2): 101-19. PMID 14592341.
^ Allen RP, Walters AS, Montlplaisir J, et al. (2005). "Restless legs syndrome prevalence and impact.". Arch Int Med 165: 1286-1292.
^ http://www.sleepfoundation.org/sleeplibrary/index.php?id=66
^ Ekbom, K.-A. Restless legs: a clinical study. Acta Med. Scand. (Suppl.) 158: 1-123, 1945.
^ Connor J, Boyer P, Menzies S, Dellinger B, Allen R, Ondo W, Earley C (2003). "Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome.". Neurology 61 (3): 304-9. PMID 12913188.
^ Desautels A, Turecki G, Montplaisir J, Sequeira A, Verner A, Rouleau G (2001). "Identification of a major susceptibility locus for restless legs syndrome on chromosome 12q.". Am J Hum Genet 69 (6): 1266-70. PMID 11704926.
^ Levchenko A, Montplaisir J, Dubé M, Riviere J, St-Onge J, Turecki G, Xiong L, Thibodeau P, Desautels A, Verlaan D, Rouleau G (2004). "The 14q restless legs syndrome locus in the French Canadian population.". Ann Neurol 55 (6): 887-91. PMID 15174026.
^ Mayo Clinic Algorithm also available as .pdf

[edit] Sources

Medcalf P, Bhatia K (2006). "Restless legs syndrome.". BMJ 333 (7566): 457-8. PMID 16946320.
"Treatment of restless legs syndrome", Pharmacist's Letter/Prescriber's Letter, 2005;21(6):210606.
MD Virtual University http://www.mdvu.org/library/disease/rls/
The International Restless Legs Study Group http://www.irlssg.org/
Schul M, McDonagh B, Guptan RC Restless Legs Syndrome
synd/2337 at Who Named It

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